Impact of bioreactor scale on lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture

Journal title

Chemical and Process Engineering




No 1 March



lovastatin ; Aspergillus terreus ATCC 20542 ; shake flask ; stirred tank bioreactor ; batch process

Divisions of PAS

Nauki Techniczne




Polish Academy of Sciences Committee of Chemical and Process Engineering




Artykuły / Articles


DOI: 10.2478/v10176-012-0007-0 ; ISSN 0208-6425


Chemical and Process Engineering; 2012; No 1 March; 71-84


Bizukojć M. (2007a), A macrokinetic modelling of the biosynthesis of lovastatin by, Aspergillus terreus. J. Biotechnol, 130, 422, ; Bizukojć M. (2007b), Simultaneous biosynthesis of (+)-geodin by a lovastatin-producing fungus, Aspergillus terreus. J. Biotechnol, 132, 453, ; Bizukojć M. (2008), Biosynthesis of lovastatin and (+)-geodin by <i>Aspergillus terreus</i> in batch and fed-batch culture in the stirred tank bioreactor, Biochem. Eng, 42, 198, ; Bizukojć M. (2011), Lovastatin and (+)-geodin formation by <i>Aspergillus terreus</i> ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources, Eng. Life Sci, 11, 272, ; J. Casas Lopez (2003), Production of lovastatin by <i>Aspergillus terreus:</i> effects of C:N ratio and the principal nutrients on growth and metabolite production, Enzyme Microb. Technol, 33, 270, ; J. Casas Lopez (2004), Fermentation optimization for the production of lovastatin by <i>Aspergillus terreus</i>; use of response surface methodology, J. Chem. Technol. Biotechnol, 79, 1119, ; J. Casas Lopez (2005), Pellet morphology, culture rheology and lovastatin production in cultures of, Aspergillus terreus. J. Biotechnol, 116, 61, ; Hajjaj H. (2001), Lovastatin biosynthesis by <i>Aspergillus terreus</i> in a chemically defined medium, Appl. Environ. Microbiol, 67, 2596, ; Kennedy J. (1999), Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis, Science, 284, 1368, ; Kumar M. (2000), Repeated fed-batch process for improving lovastatin production, Proc. Biochem, 36, 363, ; Lai L-S. (2002), Medium optimization for lovastatin production by Aspergillus terreus in submerged cultures, J. Chin. Inst. Chem. Engrs, 33, 517. ; L-S Lai (2005), The influence of culturing environments on lovastatin production by <i>Aspergillus terreus</i> in submerged cultures, Enz. Microb. Technol, 36, 737, ; Manzoni M. (1998), Production of statinsby filamenous fungi, Biotechnol. Lett, 21, 253, ; E. Rodriguez Porcel (2006), <i>Aspergillus terreus</i> broth rheology, oxygen transfer, and lovastatin production in a gas-agitated slurry reactor, Ind. Eng. Chem. Res, 45, 4837,

Editorial Board

Editorial Board

Ali Mesbach, UC Berkeley, USA

Anna Gancarczyk, Institute of Chemical Engineering, Polish Academy of Sciences, Poland

Anna Trusek, Wrocław University of Science and Technology, Poland

Bettina Muster-Slawitsch, AAE Intec, Austria

Daria Camilla Boffito, Polytechnique Montreal, Canada

Donata Konopacka-Łyskawa, Gdańsk University of Technology, Poland

Dorota Antos, Rzeszów University of Technology, Poland

Evgeny Rebrov, University of Warwick, UK

Georgios Stefanidis, National Technical University of Athens, Greece

Ireneusz Grubecki, Bydgoszcz Univeristy of Science and Technology, Poland

Johan Tinge, Fibrant B.V., The Netherlands

Katarzyna Bizon, Cracow University of Technology, Poland

Katarzyna Szymańska, Silesian University of Technology, Poland

Marcin Bizukojć, Łódź University of Technology, Poland

Marek Ochowiak, Poznań University of Technology, Poland

Mirko Skiborowski, Hamburg University of Technology, Germany

Nikola Nikacevic, University of Belgrade, Serbia

Rafał Rakoczy, West Pomeranian University of Technology, Poland

Richard Lakerveld, Hong Kong University of Science and Technology, Hong Kong

Tom van Gerven, KU Leuven, Belgium

Tomasz Sosnowski, Warsaw University of Technology, Poland