An efficiency of the nonsingular meshless method (MLM) was analyzed in an acoustic indoor problem. The solution was assumed in the form of the series of radial bases functions (RBFs). Three representative kinds of RBF were chosen: the Hardy’s multiquadratic, inverse multiquadratic, Duchon’s functions. The room acoustic field with uniform, impedance walls was considered. To achieve the goal, relationships among physical parameters of the problem and parameters of the approximate solution were first found. Physical parameters constitute the sound absorption coefficient of the boundary and the frequency of acoustic vibrations. In turn, parameters of the solution are the kind of RBFs, the number of elements in the series of the solution and the number and distribution of influence points. Next, it was shown that the approximate acoustic field can be calculated using MLM with a priori error assumed. All approximate results, averaged over representative rectangular section of the room, were calculated and then compared to the corresponding accurate results. This way, it was proved that the MLM, based on RBFs, is efficient method in description of acoustic boundary problems with impedance boundary conditions and in all acoustic frequencies.