This study illustrates the benefits of statistical techniques to analyze spatial and temporal variations in water quality. In this scope water quality differentiation caused by anthropogenic and natural factors in the Tahtali and Balçova reservoirs in western Turkey was investigated using discriminant analysis-DA, Mann Whitney U techniques. Effectiveness of pollution prevention measures was analyzed by Mann Kendall and Sen’s Slope estimator methods. The water quality variables were divided into three groups as physical-inorganic, organic and inorganic pollution parameters for the study. Results showed that water quality between reservoirs was differentiated for “physical-inorganic” and “organic pollution” parameters. Degree of influence of water quality by urbanization was higher in the Tahtali reservoir and in general, no trend detection at pollution indicators explained by effective management practices at both sites.