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Abstract

This paper presents the innovative activity of enterprises as a process that is risky but necessary for the survival of a company in a competitive market, and as a way to maximize the long-term value for the owners. Risks and benefits were analysed, and the possible sources of added value in innovative projects were identified in the context of the capital market equilibrium and the budgeting of investments. Innovative projects become a source of added value for investors if the financial effects such as changes in the residual cash flow and higher growth rate outweigh the combined impact on the risk generated by two factors: increase of systematic risk and emerging specific risks.
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Abstract

The aim of the study was to evaluate the combined effect of noise exposure and additional risk factors on permanent hearing threshold shift. Three additional risk factors were: exposure to organic solvents, smoking and elevated blood pressure. The data on exposure and health status of employees were collected in 24 factories. The study group comprised of 3741 noise male exposed workers of: mean age 39±8 years, mean tenure 16±7 years and LEX,8h = 86 ± 5 dB. For each subject, hearing level was measured with pure tone audiometry, blood pressure and noise exposure were assessed from the records of local occupational health care and obligatory noise measurements performed by employers. Smoking and solvent exposure were assessed with questionnaire. The study group was divided into subgroups with respect to the considered risk factors. In the analysis, the distribution of hearing level of each subgroup was compared to the predicted one which the standard calculation method described in ISO 1999:1990. For each of the considered risk factors, the difference between measured and calculated hearing level distribution was used to establish, by the least square method, a noise dose related correction square function for the standard method. The considered risk factors: solvent exposure, smoking and elevated blood pressure combined with noise exposure, may increase degree of hearing loss.
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Abstract

Introduction: Clostridium difficile (C. difficile) is a Gram-positive, anaerobic rod-shaped bacteria, widely spread in the human environment. In the last decade, the frequency and severity of Clostridium difficile infection (CDI) have been increasing, making this particular disease one of the most significant nosocomial infections. The aim of our study was an analysis of CDI risk factors, its course and consequences. Materials and Methods: Medical documentation of the patients treated for CDI in the University Hospital in Cracow and St Anne’s Hospital in Miechów has been analysed. The analysis focused on epidemiological data, blood parameters, comorbidities, recurrence rate, and complication rate (deaths included). As part of risk factors analysis, antibiotic use or hospitalisation in a period of 3 months before the episode of infection was considered relevant. Blood tests have been performed using routinely employed, standard methods. Results: We evaluated data of 168 people infected with C. difficile, out of which there were 102 women (61%) and 66 men (39%). Th e median age of the patients was 74 years for the entire population with 76 years for women and 71 years for male patients. One hundred thirteen people (67%) had been previously hospitalised, and 5 person was a pensioner of a nursing home. 99 people (59%) were treated with antibiotics within 3 months before the first episode of infection. An average length of the hospital stay because of CDI was 11 days. One hundred thirty persons (77%) experienced only 1 episode whereas 38 people (23%) had more than 1 episode of infection. The person with the largest number of recurrences had 9 of them. Conclusions: The development of CDI is an increasing problem in a group of hospitalised persons, particularly of an old age. The general use of beta-lactam antibiotics is the cause of a larger number of infections with C. diffi cile. Vast majority of patients have had at least one typical risk factor of CDI development.
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