Several human studies have reported that capsaicin has anti-pruritic effects. Moreover, sever- al concentrations of topical capsaicin have been used to alleviate itch. The aim of this study was to investigate the anti-pruritic effect of capsaicin against histamine-induced pruritus compared with that of topical steroid or vehicle in 15 healthy beagles. Fifteen dogs were divided into three groups (n = 5 each), and treated topically with one of the following on the left side of the neck: capsaicin, positive control (steroid), or negative control (vehicle). Each treatment was performed twice daily for 8 days. All dogs were injected with histamine intradermally before treatment and on the 2nd, 4th, 6th, and 8th days of the treatment to evoke itch. Pruritus, wheal, and erythema intensity were assessed at each evaluation; cutaneous temperature was also recorded. On the final day, skin biopsy was conducted for histopathological evaluation for all dogs. The severity of pruritus was lesser in the capsaicin-treated group compared with the negative control group on day 8 (p<0.05). In the capsaicin and steroid groups, wheal size, erythema index, and cutaneous temperature also decreased compared with pretreatment. Histopathological evaluation showed that the capsaicin-treated group had a higher number of inflammatory cells in the dermis com- pared to the vehicle control group; however, the steroid-treated group showed less severe inflam- matory reactions than the vehicle control group. These results suggest that capsaicin cannot reduce inflammation but may play a helpful role in reducing pruritus in dogs.
The paper presents an analysis of the influence of the energy generated from renewable sources on an improvement in the energy efficiency of public utility building and households. It also presents the current state of the technologies for the production of electricity from renewable sources, as well as their share in the national power supply system. The conducted analysis concerns both micro, as well as large systems generating electricity. Systems generating power from renewable sources are gaining in popularity. With an increasing awareness in the society of the beneficial influence that renewable power generating systems have on the environment, as well as the support in form of various programs offering subsidies for the construction of new systems, power generation from renewable sources is becoming increasingly popular and common. Although the renewable energy systems are still not widely considered to be a profitable solution, systems using renewable sources of energy are positively perceived and treated as a new trend in the construction of multi or single-family residential buildings. The increasing share of the renewable energy in the national power supply system significantly reduces the demand for energy produced from conventional sources. This obviously translates into a reduced consumption of primary energy, for example, fossil fuels, and, in turn, leads to the reduced exploitation of natural resources, thus contributing to the protection of the natural environment. A reduced consumption of fossil fuels also means a significant reduction in environmental pollution during their processing into electricity or heat. Actions aiming at improving energy efficiency and reducing final energy consumption are being undertaken by many countries all over the world, and by the European Union. In 2012, the European Parliament and the Council issued Directive 2012/27/EU obliging the Member States to initiate actions aiming at a reduction in the consumption of final energy by 1.5% a year. The paper presents the current status of generation of energy from renewable sources during the last 13 years. The ways for using energy from the renewable sources to improve the energy efficiency of facilities were also discussed.
Empathy and psychopathy seem to be two distant extremes, which only differ, with nothing similar. Therefore, the question that seems to be surprising is whether such a theoretical perspective is justified. Empathy exerts significant influence on social relationships and is associated with moral development, whereas psychopathy seems to be an opposite phenomenon, as it is associated with the lack of deep interpersonal bonds and the violation of legal norms. As studies from various disciplines and scientific areas indicate, such concepts as behavioral effectiveness, morality or altruism might help explain the complex nature of the interrelationship between psychopathy and empathy. The authors tried to explore and describe the complexity of the two presented concepts in the light of the conducted research, and the resulting theoretical and empirical implications.
This paper reports the results of an analysis of indicators describing the effectiveness of actions taken and repairs made by the maintenance services in a food industry company which had implemented a new manufacturing execution system (MES) 10 months prior to the study. The application of the above effectiveness indicators plays a significant role in the rationalization of functioning of maintenance services. Therefore, it is vital that they are calculated correctly and interpreted in a way that has a positive effect on the organization of maintenance works. The paper investigates four effectiveness indicators employed by the maintenance services of the company in question, i.e., mean time to failure (MTTF), mean time between failures (MTBF), mean time to repair (MTTR) and overall equipment effectiveness (OEE). The objective of the analysis was to verify the correctness of determination of the above indicators in the analysed company. In addition, the study was to determine whether the use of correctly determined indicators and results interpretation could lead to a higher effectiveness of the actions taken by the maintenance services department. Moreover, the paper presents a diagnosis of problems connected with incorrect determination and visualization of the above-mentioned indicators in the analysed company.
The paper presents an analysis of the sustainable development of electricity generation sources in the National Power System (NPS). The criteria to be met by sustainable power systems were determined. The paper delineates the power balance of centrally dispatched power generation units (CDPGU), which is required for the secure work of the NPS until 2035. 19 prospective electricity generation technologies were defined. They were divided into the following three groups: system power plants, large and medium combined heat and power (CHP) plants, as well as small power plants and CHP plants (distributed sources). The quantities to characterize the energy effectiveness and CO2 emission of the energy generation technologies analyzed were determined. The unit electricity generation costs, discounted for 2018, including the costs of CO2 emission allowance, were determined for the particular technologies. The roadmap of the sustainable development of the generation sources in the NPS between 2020 and 2035 was proposed. The results of the calculations and analyses were presented in tables and figure
The work presents the results of studies on dependence of effectiveness of chosen robust estimation methods from the internal reliability level of a geodetic network. The studies use computer-simulated observation systems, so it was possible to analyse many variants differing from each other in a planned way. Four methods of robust estimation have been chosen for the studies, differing substantially in the approach to weight modifications. For comparative reasons, the effectiveness studies have also been conducted for the very popular method in surveying practice, of gross error detection basing on LS estimation results, the so called iterative data snooping. The studies show that there is a relation between the level of network internal reliability and the effectiveness of robust estimation methods. In most cases, in which the observation contaminated by a gross error was characterized by a low index of internal reliability, the robust estimation led to results being essentially far from expectations.
This article explores the role of recognition in State creation. Basing on an analysis of relations between effectiveness and legality in the process of State creation, it claims that recognition is constitutive of statehood as a subject of international law. The research revolves around the following themes: the role of effectiveness criteria and the conditions of recognition set by international law, the existence of “statehood without effectiveness” in cases of limited effectiveness but general recognition, the study of acquisition of statehood as a process and the notion of collective recognition based on the cases of Kosovo and Palestine. The argumentation is also supported by the analysis of de facto entities and aspiring States in international practice. It draws on the distinction between legal non-recognition and political non-recognition as able to shed some light on the complexity of international practice in this area. The article concludes that recognition is a pre-requisite of statehood, an essential criterion that may overcome weak effectiveness in certain legal contexts, though not a lack of independence. Conversely, effectiveness of government authority over population and territory does not lead to statehood in the meaning of international law in the absence of international recognition.
Over the past few years, a great deal of research has been conducted concerning the mathematical skills of children after the first stage of education. In my report, I present a selection of results from this research in order to illustrate the most typical didactical effects of the style in which mathematical education is performed in our schools. Comparing some detailed results from research in a number of chosen fields, I also try to assess whether or not, and how, the level of schoolchildren’s skills has changed in the recent years.
The category of expectation constitutes an important element of reflection in many scientific disciplines focusing on man. it is treated in both the categories of expectations inscribed in large social projects (e.g. of utopian nature) and individual expectations which build human daily routine. The article is divided into two parts. in the first, the issues of interpersonal expectations, analysed in the perspective of social psychology and sociology, will be undertaken. what will be explored here are the problems of defining the notion of expectation and the problems of expectations at school, which will be exemplified by the pygmalion effect. The first part is completed with some considerations on the meaning of expectation in sociology, the role of expectations in interaction, and the relations between expecting and social order. In the second part, the author focuses on the issues of expectations inscribed in utopian projects (“great expectations”). pedagogical utopias and relations between utopias and popularization of normative (formal) or informal pedagogies are subjected to analysis. The author makes here some references to the concept of post-materialistic society, attempting to elicit relations between this type of society and popularization of nonformal pedagogies.
The aim of this article is to defi ning problems occurring in the spatial management system, including those independent of subsequent legislative changes. The process of adopting decisions to be viable and socially equitable and execute the requirements of spatial order and sunstainable development requires fundamental changes. The study draws a conclusion – important in the context of subsequent research activities – that the varied application of development decisions in diff erent municipalities is also the result of not preparing a large part of the representatives of municipalities for specifi c spatial activities.
In the current study, twenty lambs, aged 4 months, half male and half female, were classified into four groups, with five in each group. The experimental three groups of lambs were given intravenous (IV), intramuscular (IM) and subcutaneous (SC) administrations of recombinant ovine interferon-τ (roIFN-τ). The fourth group (normal control) of lambs was given normal saline injections in the same way. After administrations, blood samples were collected from the tested animals at different time points post injection, and the serum titers of roIFN-τ were measured using cytopathic effect (CPE) inhibition bioassay. The results of calculating pharmacokinetic (PK) parameters using DAS software showed that the PK characteristics of roIFN-τ through IV injection conformed to the two-compartment open model, whose half-life of distribution phases (T1/2α) was 0.33±0.034 h and the elimination half-life(T1/2β) was 5.01±0.24 h. However, the PK features of IM injection and SC injection of roIFN-τ conformed to the one compartment open model, whose Tmax were 3.11±0.26 h and 4.83±0.43 h, respectively, together with an elimination half life(T1/2β) of 9.11±0.76 h and 7. 43±0.58 h, and an absorption half-life (T1/2k(a)) of 1.13±0.31 h and 1.85±0.40 h, respectively. The bioavailability of roIFN-τ after IM administration reaches 73.57%, which is greater than that of SC administration (53.43%). These results indicate that the drug administration effect can be preferably obtained following a single dose IM administration of the roIFN-τ aqueous preparation. This study will facilitate the clinical application of roIFN-τ as a potential antiviral agent in future work.
The aim of the article is to examine the specific properties of language actions in terms of their moral evaluation. The author starts from the question whether responsibility for words has the same meaning as responsibility for a physical action. In her analysis, the author deliberates whether in both cases the same rules and criteria are applicable. Referring to the classical theory of speech acts proposed by John L. Austin, who introduced a fundamental division into constative and performative utterances and went on to distinguish illocutionary effects from perlocutionary consequences of speech acts, the author investigates how far a subject is responsible for the words he uses.
Clusters belong to the regional innovation system, which led to the formulation and implementation of the cluster-based policy in many countries. The positive impact of clusters on the competitiveness of regions was confirmed by empirical studies. Absence of clusters means retardation in a regional development. The implementation of cluster policy supporting coopetition into the scope of principled regional policy assumptions seems urgent. In this way effective conditions for the formation of growth poles around industries specific for a given region will be developed and, consequently, the economic specialization of individual regions will be achieved. Observation of the benefits resulting from the functioning of clusters in the region, taking into account their possible negative impact, will allow to determine the specificity of regional development policy based on clusters. These problems indicated above are the subject of this study, based on the Polish and foreign literature available on the subject employing the desk research method.
Internalization of external economic effects on urban sprawl affected areas. An example of the Krakow Metropolitan Area, The study is a discussion on economic externalities, with particular emphasis on technological effects. Attention is also paid to the problem of internalization of economic external effects caused by movement (transport) in areas affected by the urban sprawl process. The research was conducted for all communes of the Krakow Metropolitan Area (KOM), as a result of which the value of: directly incurred financial losses and the value of lost time generated by the necessity of commuting and return in the space of KOM were presented.
The instability characteristics of a dielectric fluid layer heated from below under the influence of a uniform vertical alternating current (AC) electric field is analyzed for different types of electric potential (constant electric potential/ electric current), velocity (rigid/free) and temperature boundary conditions (constant temperature/heat flux or a mixed condition at the upper boundary). The resulting eigenvalue problem is solved numerically using the shooting method for various boundary conditions and the solution is also found in a simple closed form when the perturbation heat flux is zero at the boundaries. The possibility of a more precise control of electrothermal convection (ETC) through various boundary conditions is emphasized. The effect of increasing AC electric Rayleigh number is to hasten while that of Biot number is to delay the onset of ETC. The system is more stable for rigid-rigid boundaries when compared to rigid-free and least stable for free-free boundaries. The change of electric potential boundary condition at the upper boundary from constant electric potential to constant electric current is found to instill more stability on the system. Besides, increase in the AC electric Rayleigh number and the Biot number is to reduce the size of convection cells.
The effectiveness of cast iron spheroidization with FeSiMg master alloy by the traditional method and using a reaction chamber placed in the cavity of foundry mould was compared. The method of cast iron treatment in mould cavity using a reaction chamber is an innovative technology developed by the Foundry Research Institute in Krakow. The effectiveness of the spheroidization process carried out by both methods was checked on a series of test castings. The article also presents the results of metallographic examinations and mechanical testing, including the discussion of magnesium yield and its assimilation rate.
The subject of the research is one of the largest World’s mine tailings disposal sites, i.e. Żelazny Most in the Legnica-Głogów Copper Mining District (south-western Poland), where flotation tailings are poured out after copper ore treatment. The protective hydraulic barrier made of 46 vertical drainage wells was characterized and evaluated in view of reduction of major contaminants (Cl, Na, SO4, Ca) migrating from the facility to its foreground. The efficiency of groundwater protection was determined on the basis of a new approach. In applied method the loads of characteristic and commonly recognizable compounds, i.e. salt (NaCl) and gypsum (CaSO4) were calculated, instead their chemical components. The temporal and spatial variability of captured main contaminants loads as well as its causes are discussed. The paper ends with the results of efficiency analyses of the barrier and with respect to the predicted increase in contaminant concentrations in the pulp poured out to the tailings site.
Scientific output analysis in Poland takes place in many ways: by use both central and local databases. The article discusses the contents and bibliometric functions of the most important bibliographic databases, i.e. “People of science”, Polish Scientific Bibliography and employeers local registration system Expertus. The authors evaluate these tools from the perspective of the ability to make comparisons of the effectivity of individual researchers as well as to stimulate the development of scientific careers. As alternative solution relative to the analytical spectrum of all external tools, the authors present own application that allows visualization of scientific achievements. According authors’ observation, the Scientific Visualiser can enrich the individual information space of the contemporary scientist. Dedicated application certainly facilitates the evaluation of the publication activity, increases an awareness of updating of the bibliographic data, helps in discovering the relationship between the research fields, inspires to broaden intelectual horizons and cooperation networks. From another side, it can also be a tool supporting administration activities, such as: employees evaluation, promotion proceedings, accreditation, experts selection, distribution of funds.
Transverse effective thermal conductivity of the random unidirectional fibre-reinforced composite was studied. The geometry was circular with random patterns formed using random sequential addition method. Composite geometries for different volume fraction and fibre radii were generated and their effective thermal conductivities (ETC) were calculated. Influence of fibre-matrix conductivity ratio on composite ETC was investigated for high and low values. Patterns were described by a set of coordination numbers (CN) and correlations between ETC and CN were constructed. The correlations were compared with available formulae presented in literature. Additionally, symmetry of the conductivity tensor for the studied geometries of fibres was analysed.
The arc suppression coil determines whether it can effectively extinguish the arc when it is grounded in the neutral non-effective grounding system. An artificial grounding test is an importantway to verify its performance. In this study, 13 substations with the 10 kV system in the Ningxia areawere selected and considered. Based on the artificial single-phase grounding test, the residual current, the compensation current and the off-resonance degree were measured in the arc suppression coil, and the performance of the arc suppression coil in the 10 kV system was verified. The experimental results show that the error of arc suppression coil automatic measurement is large, the off-resonance degree is large, the resistive component in the compensation current is excessive, the harmonic component exists in the compensating current and capacitive current. To solve these problems, this paper puts forward the corresponding countermeasures for reference.