7N01-T4 aluminum alloy was welded by metal inert gas welding and the influence of V-groove angle on joint fatigue properties was investigated. The results indicate that the volume of fusion zone (FZ) and the grains in FZ become small when the groove angle decreases to 50° from 70°. Most pores distribute at the FZ edge and fewer pores are formed in the small angle joint. The fatigue crack mainly initiates at the transition region between the weld passes due to the pore concentration. The small angle contributes to increasing joint fatigue properties, especially at the low stress level. The fatigue strength of 50° joint is 103.06 MPa which is 15.3% higher than that of 70°joint.