O b j e c t i v e s: Pill-takers seem to have some deficiencies in developing problem-solving styles, in which it plays an important role in their mental health. The present study has aimed to examine the role of problem-solving styles in individuals who have suicidal behavior by taking pills. M e t h o d s: This research is a case-control study in which 100 people who had attempted to commit suicide by taking pills and had gone to the toxicity emergency room of the Razi Educational and Therapeutic center in Rasht city, were compared with 100 normal people who were selected as the control group. These two groups of people were compared with each other in terms of their problem-solving styles (which is measured using Cassidy and Long problem solving styles questionnaire). R e s u l t s: After adjusting the effects of the confounding variables, i.e. level of education, marital status, residential status, history of psychiatry and alcohol addiction, it became clear that pill-takers group in comparison with the control group scores significantly higher in the non-adaptive problem-solving styles i.e. helplessness, problem-solving control, and avoidance styles (P < 0.0001) and also lower scores in adaptive styles, i.e. creative, confidence and approach styles (P < 0.0001). The interactive effects of group membership and gender were not significant in any of the problem-solving styles (P < 0.05). C o n c l u s i o n s: Problem-solving styles are regarded as important risk factors when it comes to attempting to commit suicide by taking pills. Thus, it is essential to teach problem-solving styles to at-risk patients in order to preventing suicidal behavior.