Vaccination is a common routine for prevention and control of human and animal diseases by inducing antibody responses and cell-mediated immunity in the body. Through vaccinations, smallpox and some other diseases have been eradicated in the past few years. The use of a patho- gen itself or a subunit domain of a protein antigen as immunogens lays the basis for traditional vaccine development. But there are more and more newly emerged pathogens which have expe- rienced antigenic drift or shift under antibody selective pressures, rendering vaccine-induced im- munity ineffective. In addition, vaccine development has been hampered due to problems includ- ing difficulties in isolation and culture of certain pathogens and the antibody-dependent enhancement of viral infection (ADE). How to induce strong antibody responses, especially neu- tralizing antibody responses, and robust cell-mediated immune responses is tricky. Here we re- view the progress in vaccine development from traditional vaccine design to reverse vaccinology and structural vaccinology and present with some helpful perspectives on developing novel vac- cines.
The aim of the study was to examine the relationships of Level -1/Level -2 visual perspective -taking (VPT -1/VPT -2) with theory of mind (ToM) and executive function (EF). Seventy -six adults aged 18 to 48 years participated in the study. To compare the relationships of the two levels of perspective -taking with the aforementioned abilities, the same stimuli were used in both Level -1 and Level -2 trials of the VPT task. ToM abilities were evaluated with the Strange Story task, and EF using the TMT and WCST tests. It was found that controlling for age -related differences, VPT -1 was not associated with either ToM or such components of EF as executive control and set -shifting. VPT -2 was positively related to ToM, but it was not related to EF. The relationship between VPT -2 and ToM was specific, not mediated by domain -general processing capabilities. The obtained results provide further evidence to support the view that distinct mechanisms underlie Level -1 and Level -2 perspective -taking.
It is nearly impossible to study behaviour effectively without any reference to its context. This is because it is generally known in the psychological literature that behaviour is partially a product of its environment. This suggests that many behavioural processes may be universal but there are significant variations in their manifestations. For instance, love may be a universal process but its manifestation varies from one society to another. Given that ethical decision-making is a behavioural process, it stands to reason that its manifestation will vary from one culture to another. It is against this premise that this paper seeks to demonstrate that despite the existence of the ‘universal’ normative ethical principles, ethical decisions will be expected to vary across cultural space and even evolve with time. This paper achieves this objective by employing typical ethical dilemmas that Ghanaian psychologists and other health professionals encounter to show how and why what is ethical in one culture becomes unethical in the Ghanaian context and what is unethical in the Ghanaian context becomes ethical in another culture.
In these remarks I recall the attempts of pointing out the relations between philosophy and modernity in sciences in three distinctively differing point of view, that is the achievements of “the Enlightened Age” (in the sense of Ernst Cassirer), phenomenological philosophy (in the sense of Edmund Husserl) and the classicist conservatism (in the sense of Allan Bloom). In each of these cases an importance of those relations is being acknowledged. However it is not just differently evaluated and justified, but also the diagnoses and forecasts related to it look differently either.
This article addresses the issue of the role of regions, big cities and urban areas in the socio-economic and spatial development trends in the EU as well Poland shaped through – and in connection with the process of globalization and functioning of the Common Market. The analysis of the situation and trends is prepared on the basis of the recent reports and data presented by the EC and OECD and – in case of Poland – Ministry of Investment and Economic Development as well Main Statistical Offi ce. Against this background with the reference to other research work published recently and his own experience the Author formulates a number of proposals for modification of territorially sensitive socio-economic policy in Poland (at national, regional as well urban level).
The ideas of pluralism, their various theoretical developments and ideological concretizations, as well as their promotion and the attempts at implementing them in social practice, constitute a current signum temporis. Pedagogical reflection seems to be particularly sensitive to the issue of pluralism, to its understanding and practising, to multidimensional references of pluralism to the world of values. This especially concerns the values and conflicts of values which are close to various forms of educational activity. What is considered – more or less critically – in pedagogical reflection are different aspects and consequences of the idea of pluralism concerning the currently existing ideas. Simultaneously, the multitude of the ideas of pluralism is taken into account – the ideas which refer to the broadly treated sphere of pedagogical activities and institutions. Pedagogical reflection also considers the threats which co-occur with pluralism or are aimed against it and which are carried by pluralism itself, e.g. in the sphere of education. An expert in the contemporary pedagogical thought and practice, Bogusław Śliwerski, asks: “Will we manage to save the world of pedagogical thought, the pedagogy open to difference, to pluralism (not to be mistaken for another illness which is relativism)?”. By confronting pluralistic perspectives of pedagogy with current ideological and social challenges, he makes this question one of the leading issues in pedagogical and metapedagogical studies. What seems to be heard in this question as well is the appeal to save the world of pedagogical thought as an open world characterized by pluralism, doing this through honest reasoning conducted from different standpoints and perspectives. The assumption of this question comprises the axiologically consolidated belief that it is worth “to save the world of pedagogical thought, the pedagogy open to pluralism”. This is also an inspiration to undertake the (presented in this text) thought concerning the pluralistic perspectives of pedagogy and various faces of pluralisms in the critical recognition of metapedagogical reflection in the case of the Polish pedagogical thought after 1989.