The paper presents a procedure for correction of the error of an ECG signal, introduced by the skin-electrode interface. This procedure involves three main measuring-calculating stages: parametrical identification of the mathematical model of the interface, realized directly before the diagnostic measurements, registration of the signal at the output of electrodes as well as reconstruction of the input signal of the interface. The first two stages are realized in the on-line mode, whereas the operation of signal reconstruction presents a numerical task of digital signal processing and is realized in the off-line mode through deconvolution of the registered signal with the transfer function of the skin-electrode interface. The aim of the paper is to discuss in detail the procedure of parametric identification of the skin-electrode interface with the use of a computer system equipped with a DAQ card and LabVIEW software. The algorithm for error correction introduced by this interface is also presented.