Dendritic cells (DCs) due to their ability to present antigens are essential during the immune response to infections. The aim of the study was to evaluate the influence of bovine leukaemia virus (BLV) infection on DC properties. Cytokine profiles of myeloid, plasmacytoid and mono- cyte derived DCs from BLV infected cattle were analysed. Concentrations of IL-6, IL-10, IL-12, IFN-γ, and TNF-α in DC cultures were measured by flow cytometry. Obtained results indicated activation of pDCs population, where a significant increase in production of the IFN-γ was shown. Meanwhile, a decrease in production of IFN-γ and increase in production of IL-10 were shown in mDCs; the main population responsible for antigens presentation. This may indicate a contribu- tory role of the population during the process of persistent infection. In MoDCs population a significant elevation in secretion of proinflammatory cytokines – IL-6 and TNF-α was noted.
Local service centre, defined as multi-functional public space providing access to everyday services, promoting social integration and building local identity, is an essential hub in the urban service sector. From the public policy perspective appropriate location and furnishing of local service centres is a basic condition for shaping territorial cohesion. This paper synthesises the to-date knowledge on mechanisms determining the development of service sector in cities, including new phenomena such as decentralisation of urban functions, urban shrinkage, remote services provision or commercialisation of lifestyle. Critical literature review enables the confrontation of various research perspectives and leads to distinguishing key factors affecting the development of urban local service centres in the first half of 21st century and defining the current challenges for public policy.