O b j e c t i v e s: The aim of study was to investigate the association between anxiety, depression, stress and determinants of quality of life among Iranian students. M e t h o d s: The questionnaires were completed by 275 students. The random sampling was conducted in two phases, the stratified sampling which some classes were selected among different classes of faculty of health and at the second phase, in each class the number of students who had the requirements to enter in the study were selected randomly. the logistic regression to find out the association between demographic characteristics with the quality of life was run and according to the normality status of the distribution of data the parametric or non-parametric tests were used. R e s u l t s: In the univariable model, the students that were living in their own homes had the odds of 2.18 times more than the others to have a higher quality of life level (95% CI: 1.07–4.45). In the multi variable model the anxiety and stress were significantly related to the quality of life and for increasing each 1 unit in the amount of anxiety and stress the odds of a better quality of life decreases 0.19 and 0.03 respectively. Even after adjusting for other covariates – in the multivariable model – both anxiety and stress were associated with the quality of life. C o n c l u s i o n: It is useful for the universities to understand different aspects of the students’ lives which are under the influence of stress, anxiety and depression, and also determining the resources from which they are originated.