Both sarcoidosis and primary Sjögren syndrome (pSS) are multisystem disorders of unknown etiology, which share certain clinical features, making the diff erential diagnosis a real challenge in clinical practice. Several published case reports and case series have posed the question as to whether there is a real association — mimicry between the two diseases or it is just coincidence. We attempt, aft er systematic and comprehensive research of the relevant published literature, to present all those data, clinical or paraclinical, which could be useful in the diagnostic approach and the distinguishment of the two diseases. It is certain that, besides the classic diagnostic methods, emerging is the role of immunology and genetics on this direction, although not established yet.
Hypertension constitutes one of the most common diseases leading patients to the Outpatient Departments. Idiopathic hypertension is the prevailing type, but on the other hand, the possible presence of clinical entities responsible for the development of secondary hypertension should never be underestimated. We retrospectively studied 447 subjects aged between 20 and 84 years old and diagnosed with hypertension, who were thoroughly evaluated for secondary hypertension. Our analysis demonstrated that 35 out of the 447 subjects were fi nally diagnosed with secondary hypertension, representing a relative frequency of 7.8%. Most common causes of secondary hypertension identifi ed in our study group were: glucocorticoid intake (n = 14), obesity hypoventilation syndrome (n = 6), obstructive sleep apnea (n = 2) and preeclamspia (n = 2). Several other causes are also reported. Our study, conducted in a single center in Northern Greece, confi rms previous reports concerning the prevalence of secondary hypertension among Greek patients, shedding light on potential pathophysiologic mechanisms. In conclusion, a high proportion of hypertensive individuals still feature have an underlying cause, thus, diagnostic work-up should be thorough and exhaustive, in order the correct diagnosis to be made and the targeted treatment to be initiated.