TitleSupplementation of pigs diet with zinc and copper as alternative to conventional antimicrobials
Journal titlePolish Journal of Veterinary Sciences
Divisions of PASNauki Biologiczne i Rolnicze
PublisherPolish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn
ReferencesMissotten (2009), Screening of isolated lactic acid bacteria as potential beneficial strains for fermented liquid pig feed production, Anim Feed Sci Technol, 150. ; Zhang (2009), Supplemental zinc reduced intestinal permeability by enhancing occluding and zonula occludens proteins ZO expression in weaning piglets, Br J Nutr, 1. ; Pieper (2012), Dose - dependent effects of dietary zinc oxide on bacterial communities and metabolic profiles in the ileum of weaned pigs, Nutr, 825. ; Morales (2012), Zinc oxide at low supplementation level improves productive performance and health status of piglets, J Anim Sci, 436, doi.org/10.2527/jas.53833 ; Heo (2013), Gastrointestinal health and function in weaning pigs : a review of feeding strategies to control post - weaning diarrhoea without using in - feed antimicrobial compounds, Nutr, 207. ; Mavromichalis (2000), Growth - promoting efficacy in young pigs of two sources of zinc oxide having either a high or a low bioavailability of zinc, J Anim Sci, 2896, doi.org/10.2527/2000.78112896x ; Hojberg (2005), Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets, Appl Environ Microbiol, 2267, doi.org/10.1128/AEM.71.5.2267-2277.2005 ; Li (2006), a ) Dietary supplementation with zinc oxide increases Igf - I and Igf - I receptor gene expression in the small intestine of weanling piglets, J Nutr, 136. ; McAlpine (2012), The effect of seaweed extract as an alternative to zinc oxide diets on growth performance , nutrient digestibility , and fecal score of weaned piglets, J Anim Sci, 224, doi.org/10.2527/jas.53956 ; Sirelkhatim (2015), Review on zinc oxide nanoparticles : antibacterial activity and toxicity mechanism Nano, Micro Letters, 7, 219, doi.org/10.1007/s40820-015-0040-x ; Lampromsuk (2012), Effect of supplementing acidifiers and organic zinc in diet on growth performances and gut conditions of pigs, J Appl Sci, 12, 553, doi.org/10.3923/jas.2012.553.560 ; Moreno (2014), Survey of quantitative antimicrobial consumption per production stage in farrow - to - finish pig farms in Spain, Vet Rec Open, 1. ; Castillo (2008), Use of mannanoligosaccharides and zinc chelate as growth promoters and diarrhea preventive in weaning pigs : Effects on microbiota and gut function, J Anim Sci, 86, 94, doi.org/10.2527/jas.2005-686 ; Armstrong (2004), Effect of dietary copper source ( cupric citrate and cupric sulfate ) and concentration on growth performance and fetal copper excretion in weanling pigs, J Anim Sci, 1234, doi.org/10.2527/2004.8241234x ; Castro (2005), Use of additives on the feeding of monogastric animals, Cuban J Anim Sci, 439. ; Slifierz (2014), Zinc Oxide therapy increases prevalence and persistence of methicillin - resistant Staphylococcus in pigs : a randomized controlled trial, Zoonoses Public Health, 301. ; Thati (2010), Nanostructured zinc oxide enhances the activity of antibiotics againstStaphylococcus aureus, J Biosci Tech, 1. ; Hill (1983), A copper deficiency in neonatal pigs induced by a high zinc maternal diet, J Nutr, 867. ; Perez (2011), Additivity of effects from dietary copper and zinc on growth performance and fecal microbiota of pigs after weaning, J Anim Sci, 414, doi.org/10.2527/jas.2010-2839 ; Davin (2013), Effect of weaning and in - feed high doses of zinc oxide on zinc levels in different body compartments of piglets Suppl s, Physiol Anim Nutr, 6, doi.org/10.1111/jpn.12046 ; Thacker (2013), Alternatives to antibiotics as growth promoters for use in swine production : a review, J Anim Sci Biotechnol, 4. ; Davin (2012), Evolution of zinc , iron , and copper concentrations along the gastrointestinal tract of piglets weaned with or without in - feed high doses of zinc oxide compared to unweaned littermates, J Anim Sci, 248, doi.org/10.2527/jas.53999 ; Jensen (2016), National monitoring study in Denmark finds increased and critical levels of copper and zinc in arable soils fertilized with pig slurry, Environ Pollut, 214. ; Jacela (2010), Feed additives for swine : Fact sheets - high dietary levels of copper and zinc for young pigs , and phytase, J Swine Health Prod, 18, 87. ; Agga (2015), Effects of chlortetracycline and copper supplementation on the prevalence , distribution , and quantity of antimicrobial resistance gens in the fecal metagenome of weaned pigs, Prev Vet Med, 119. ; Holman (2015), Antimicrobial use in swine production and its effect on the swine gut microbiota and antimicrobial resistance, Can J Microbiol, 61, 785, doi.org/10.1139/cjm-2015-0239 ; Carlson (2004), Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose , theophylline and - HT in piglet small intestinal mucosa, Comp Biochem Physiol A, 137. ; Holzel (2012), Heavy metals in liquid pig manure in light of bacterial antimicrobial resistance, Environ Res, 21, doi.org/10.1016/j.envres.2012.01.002 ; Vondruskova (2010), Alternatives to antibiotic growth promoters in prevention of diarrhoea in weaned piglets : a review, Vet Med, 199. ; Chai (2013), Effects of zinc supplementation on virus infection in pigs Freien Universitat Berlin www diss fu - berlin de diss servlets, Journal, 3692. ; Demir (2014), Zinc oxide nanoparticles : genotoxicity , interaction with UV - light and cell - transforming potential, J Hazard Mater, 264. ; Turner (2001), Alternatives to conventional antimicrobials in swine diets, Prof Anim Sci, 17, 217. ; Malka (2013), Eradication of multi - drug resistant bacteria by a novel Zn - doped CuO nanocomposite, Small, 4069, doi.org/10.1002/smll.201301081 ; Roof (1982), Effect of carbadox and various dietary copper levels for weanling swine, J Anim Sci, 1109, doi.org/10.2527/jas1982.5551109x ; Tayel (2011), Antibacterial action of zinc oxide nanoparticles against foodborne pathogens, J Food Safety, 31, 211, doi.org/10.1111/j.1745-4565.2010.00287.x ; Cromwell (1998), Tribasic copper chloride and copper sulfate as copper sources for weanling pigs, J Anim Sci, 76. ; Cho (2015), Effects of dietary supplementation of modified zinc oxide on growth performance , nutrient digestibility , blood profiles , fecal microbials shedding and fecal score in weanling pigs, Anim Sci J, 617, doi.org/10.1111/asj.12329 ; Yin (2009), Dietary supplementation with zinc oxide stimulates ghrelin secretion from stomach of young pigs, J Nutr Biochem, 20, 783, doi.org/10.1016/j.jnutbio.2008.07.007 ; 29 (2003), Regulation No Regulation of the European Parliament and of the Council of European Union eur - lex europa edu legal - content / EN TXT / uri, Official Journal, 268. ; Sargeant (2010), Dietary zinc oxide affects the expression of genes associated with inflammation : Transcriptome analysis in piglets challenged with ETEC, Vet Immunol Immunopathol, 88, 120, doi.org/10.1016/j.vetimm.2010.05.001 ; Shelton (2011), Effects of copper sulfate , tri - basic copper chloride , and zinc oxide on weanling pig performance, J Anim Sci, 89, 2440, doi.org/10.2527/jas.2010-3432 ; Ahmed (2014), Comparison of single and blend acidifiers as alternative to antibiotics on growth performance , fecal microflora , and humoral immunity in weaned piglets Asian, Australas J Anim Sci, 27, 93, doi.org/10.5713/ajas.2013.13411 ; Hahn (2006), Effects of supplementation of beta - glucans on growth performance , nutrient digestibility , and immunity in weaning pigs, J Anim Sci, 1422, doi.org/10.2527/2006.8461422x ; Ansari (2012), Characterization of clinical strains of MSSA , MRSA and MRSE isolated from skin and soft tissue infections and the antibacterial activity of ZnO nanoparticles, World J Microbiol Biotechnol, 28, 1605, doi.org/10.1007/s11274-011-0966-1 ; Grela (2004), Nutritional and prophylactic importance of zinc in pigs production, Med Weter, 1254. ; Brugger (2015), Environmental responsibilities of livestock feeding using trace mineral supplements, Anim Nutr, 1. ; Zhou (2014), Stimulation of growth by intravenous injection of copper in weanling pigs, J Anim Sci, 2395. ; Li (2006), Effects of β - glucan extracted fromSaccharomyces cerevisiaeon growth performance , and immunological and somatotropic responses of pigs challenged withEscherichia colilipopolysaccharide, J Anim Sci, 2374, doi.org/10.2527/jas.2004-541 ; Hernandez (2008), Levels of copper and zinc in diets for growing and finishing pigs can be reduced without detrimental effects on production and mineral status, Animal, 2, 1763, doi.org/10.1017/S1751731108003182 ; Bednorz (2013), The broader context of antibiotic resistance : zinc feed supplementation of piglets increases the proportion of multi - resistantEscherichia coliin vivo, Int J Med Microbiol, 303.